fMRI replicability depends upon sufficient individual-level data

Replicability and Heterogeneity of Awake Unrestrained Canine fMRI Responses

Previously, we demonstrated the possibility of fMRI in two awake and unrestrained dogs. Here, we determined the replicability and heterogeneity of these results in an additional 11 dogs for a total of 13 subjects. Based on an anatomically placed region-of-interest, we compared the caudate response to a hand signal indicating the imminent availability of a food reward to a hand signal indicating...

Correction: Replicability and Heterogeneity of Awake Unrestrained Canine fMRI Responses

Copyright: 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Figure 4. Unthresholded t-maps of hand signal for ‘‘reward’’ vs. hand signal for ‘‘no reward.’’ The slice containing the vent...

Statistical Analysis Methods for the fMRI Data

Functional magnetic resonance imaging (fMRI) is a safe and non-invasive way to assess brain functions by using signal changes associated with brain activity. The technique has become a ubiquitous tool in basic, clinical and cognitive neuroscience. This method can measure little metabolism changes that occur in active part of the brain. We process the fMRI data to be able to find the parts of br...

Why collect individual-level vaccination data?

Laser acupuncture: effectiveness depends upon dosage.

Glazov and colleagues are to be commended for their efforts in completing a high quality, primary care-based trial of laser acupuncture in the treatment of chronic low back pain (CLBP). This is a timely and important study (see page 94): over the last several decades, back pain (and CLBP in particular), has become recognised as a prevalent, costly and largely intractable condition; laser acupun...